Understanding the molecular changes in Dementia with Lewy bodies
Identifying Pathophysiological Signatures of DLB Cognitive and Neuropsychiatric Decline Using a Systems-Based Proteomic Approach
This study is looking at how certain proteins in the brain might be linked to memory and mental health issues in people with Dementia with Lewy bodies, so we can better understand the disease and find new ways to help those affected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11046560 on NIH RePORTER |
What this research studies
This research aims to explore the underlying molecular mechanisms that contribute to cognitive and neuropsychiatric decline in patients with Dementia with Lewy bodies (DLB). By utilizing advanced proteomic techniques, the study will analyze cerebrospinal fluid samples to identify specific protein signatures associated with DLB. This approach seeks to enhance our understanding of the disease and improve monitoring and treatment strategies for affected individuals. The research is led by a team of experts in neurodegeneration and proteomics, ensuring a comprehensive and innovative methodology.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Dementia with Lewy bodies who are experiencing cognitive and neuropsychiatric symptoms.
Not a fit: Patients with other forms of dementia or neurodegenerative diseases unrelated to Lewy bodies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new biomarkers that improve the diagnosis and treatment of Dementia with Lewy bodies.
How similar studies have performed: Previous research has shown promise in identifying biomarkers for neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Higginbotham, Lenora — Emory University
- Study coordinator: Higginbotham, Lenora
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.