Understanding the molecular changes in brain cells affected by ALS
Molecular Phenotyping of Cortical Cell Types in ALS-Related Neurodegeneration
This study is looking at how ALS affects different brain cells to understand why some neurons are more likely to break down, and it hopes to find new treatments that could help people with ALS, so patients can help by sharing samples or taking part in related activities.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11080200 on NIH RePORTER |
What this research studies
This research investigates the specific molecular changes in different types of brain cells that are affected by amyotrophic lateral sclerosis (ALS). By analyzing gene expression and identifying unique pathways in these cells, the study aims to uncover why certain neurons are more vulnerable to degeneration in ALS. The approach involves advanced techniques to distinguish between similar neuron types, which could lead to targeted therapies. Patients may contribute by providing biological samples or participating in related assessments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with ALS who are willing to participate in biological sampling and assessments.
Not a fit: Patients with other neurodegenerative diseases or those who do not have a diagnosis of ALS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective therapies that halt or reverse the progression of ALS.
How similar studies have performed: Previous research has shown promise in understanding neurodegeneration through molecular profiling, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Schmidt, Eric F — Rockefeller University
- Study coordinator: Schmidt, Eric F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.