Understanding the molecular changes in ALS among U.S. military Veterans
Cell-type-specific molecular pathology of ALS in U.S. military Veterans
['FUNDING_OTHER'] · JAMES J PETERS VA MEDICAL CENTER · NIH-10948919
This study is looking at how different types of cells in the brain change when someone has ALS, especially in U.S. military Veterans, to help us understand the disease better and find new ways to treat it.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JAMES J PETERS VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (BRONX, UNITED STATES) |
| Trial ID | NIH-10948919 on ClinicalTrials.gov |
What this research studies
This research investigates the specific molecular changes in different cell types associated with amyotrophic lateral sclerosis (ALS) in U.S. military Veterans. By focusing on the unique biological characteristics of ALS, the study aims to uncover how both motor and non-neuronal cells contribute to the disease's progression. The approach involves detailed analysis of gene expression in various cell types within the brain, rather than relying on bulk brain tissue, to gain insights into the disease mechanisms. This could lead to a better understanding of ALS and potentially identify new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are U.S. military Veterans diagnosed with amyotrophic lateral sclerosis.
Not a fit: Patients who do not have ALS or are not U.S. military Veterans may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for ALS, particularly for Veterans affected by the disease.
How similar studies have performed: While research on ALS has been extensive, this specific focus on cell-type-specific molecular pathology is a novel approach that has not been widely tested.
Where this research is happening
BRONX, UNITED STATES
- JAMES J PETERS VA MEDICAL CENTER — BRONX, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DRACHEVA, STELLA — JAMES J PETERS VA MEDICAL CENTER
- Study coordinator: DRACHEVA, STELLA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Amyotrophic Lateral Sclerosis Motor Neuron Disease