Understanding the molecular causes of white matter lesions in dementia
Official title: Defining the molecular spectrum of white matter vascular lesions
Funded at University of California Los Angeles · NIH-11022547 · Data updated 2026-11-12
This study is looking at how certain brain changes related to blood vessels can affect thinking and memory in people with conditions like Alzheimer's, and it hopes to find new ways to help improve brain health and function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 17, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $4,693,249 |
| NIH project number | 1RF1NS139972-01 |
| Project ID | NIH-11022547 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with vascular cognitive impairment or dementia, particularly those with Alzheimer's disease or related disorders.
✕Less likely to help
Patients with cognitive impairments not related to vascular issues or Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the molecular characteristics of white matter vascular lesions that contribute to vascular cognitive impairment and dementia (VCID). It aims to uncover how these lesions affect brain inflammation, cell communication, and overall brain function, particularly in conditions like Alzheimer's disease. By establishing a VCID Center With Out Walls, the project will explore various therapeutic approaches to mitigate the effects of these lesions. Patients may benefit from insights into the underlying mechanisms of their cognitive impairments and potential new treatment options.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from vascular cognitive impairment and dementia.
How similar studies have gone: Previous research has shown promise in understanding the links between vascular lesions and cognitive decline, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Hinman, Jason D — University of California Los Angeles
- Study coordinator: Hinman, Jason D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.