Understanding the molecular causes of tau-related diseases in diverse populations
Official title: Molecular drivers of tauopathies in stem cell models from diverse human populations
Funded at Washington University · NIH-11101288 · Data updated 2026-11-12
This study is looking at how changes in a protein called tau can cause brain diseases, using stem cells from people of different backgrounds to find out if certain gene mutations make these conditions worse, with the hope of discovering new treatments.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | August 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $126,981 |
| NIH project number | 5K01AG083215-03 |
| Project ID | NIH-11101288 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals from diverse genetic backgrounds, particularly those with a family history of tauopathies or specific MAPT mutations.
✕Less likely to help
Patients who do not have tauopathies or related genetic mutations may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms behind tauopathies, which are diseases associated with tau protein abnormalities, using stem cell models derived from diverse human populations, including African, Asian, and South American groups. The study aims to identify specific mutations in the MAPT gene that contribute to tau toxicity and how these mutations may vary across different genetic backgrounds. By employing advanced techniques such as CRISPR-based screens and induced pluripotent stem cells (iPSCs), the research seeks to uncover unique and common molecular signatures of tauopathies that could lead to targeted therapies. The project is led by Dr. Miguel Minaya, who is receiving specialized training in stem cell biology and functional genomics.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for tauopathies, improving treatment options for affected individuals.
How similar studies have gone: Other research has shown promise in using stem cell models and CRISPR technology to study genetic diseases, indicating that this approach has potential for success.
Where this research is happening
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Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Minaya, Miguel — Washington University
- Study coordinator: Minaya, Miguel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.