Understanding the molecular causes of gastrointestinal stromal tumors (GISTs)
Project 1: Molecular Determinants of GIST Pathogenesis
This study is looking at the genetic changes in gastrointestinal stromal tumors (GISTs) to help doctors better understand which patients might be at higher risk of their cancer coming back after surgery, so they can create more tailored treatment plans.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10848814 on NIH RePORTER |
What this research studies
This research investigates the molecular factors that contribute to the development and progression of gastrointestinal stromal tumors (GISTs), a type of cancer that affects the digestive tract. By analyzing genetic alterations and biomarkers in tumor samples, the study aims to improve risk assessment models for patients with GISTs, particularly those at high risk of recurrence after surgery. The research utilizes genomic characterization techniques to identify specific mutations and alterations that may indicate aggressive tumor behavior. This information could lead to more personalized treatment strategies for patients with GIST.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with gastrointestinal stromal tumors, especially those with advanced or metastatic disease.
Not a fit: Patients with GISTs that are localized and have not progressed may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and treatment options for patients with gastrointestinal stromal tumors.
How similar studies have performed: Previous research has shown promise in identifying genetic markers in other cancer types, suggesting that this approach could yield valuable insights for GISTs as well.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Chi, Ping — Sloan-Kettering Inst Can Research
- Study coordinator: Chi, Ping
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.