Understanding the molecular causes of Alzheimer's disease
Core B: Integrative Data-Science Core
This study is looking at how certain genes might cause problems in the brain for people with Alzheimer's, using both human samples and mice, to help find better ways to understand and treat the disease.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10897917 on NIH RePORTER |
What this research studies
This research focuses on identifying the molecular drivers behind network dysfunction in Alzheimer's disease by analyzing gene regulation and various phenotypes in both human samples and mouse models. The team will employ advanced data science techniques, including machine learning and deep learning, to integrate and model complex data sets. By standardizing experimental protocols and utilizing innovative statistical methods, the research aims to provide insights that could lead to better understanding and treatment of Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those at risk for developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in using integrative data science approaches to understand complex diseases, suggesting potential for success in this novel application.
Where this research is happening
San Francisco, United States
- J. David Gladstone Institutes — San Francisco, United States (Active)
Researchers
- Principal investigator: Pollard, Katherine S. — J. David Gladstone Institutes
- Study coordinator: Pollard, Katherine S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.