Understanding the molecular and circuit mechanisms of sleep across species
Cross-Species Analyses of the Molecular and Circuit Basis ofSleep
This study is looking at how sleep works in different animals, like fruit flies and mice, to understand what controls our sleep patterns and how it affects our behavior and brain health, so we can learn more about sleep for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11084440 on NIH RePORTER |
What this research studies
This research investigates the fundamental mechanisms that regulate sleep by examining both molecular and neural circuit levels in different species, including fruit flies and mice. The team employs a multidisciplinary approach to explore how circadian rhythms influence sleep and arousal, as well as how specific neural circuits contribute to sleep drive. By studying these processes, the research aims to uncover the conserved mechanisms that govern sleep regulation and its impact on behavior and brain plasticity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing sleep disorders or disturbances, such as insomnia or irregular sleep patterns.
Not a fit: Patients with sleep disorders that are primarily psychological in nature, such as anxiety-related insomnia, may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for sleep disorders, improving overall health and quality of life for patients affected by disrupted sleep.
How similar studies have performed: Previous research has shown success in understanding sleep mechanisms through cross-species studies, indicating that this approach is promising and builds on established findings.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Wu, Mark N — Johns Hopkins University
- Study coordinator: Wu, Mark N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.