Understanding the mechanisms of heart failure and Alzheimer's disease
Official title: BLRD Research Career Scientist Award Application
Funded at VA Northern California Health Care Sys · NIH-10948898 · Data updated 2026-11-12
This study is exploring how heart failure and Alzheimer's disease develop by looking closely at the tiny processes in our cells, with the hope of finding new ways to treat these conditions and discover new medications that can help people living with them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Northern California Health Care Sys NIH-funded |
| Lab location | 1 site (Mather, United States) |
| Project start | October 1, 2021 |
| Project end | September 30, 2026 |
| Funding year | 2025 |
| NIH project number | 5IK6BX005753-04 |
| Project ID | NIH-10948898 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with heart failure or Alzheimer's disease.
✕Less likely to help
Patients with acute conditions unrelated to heart failure or Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the underlying mechanisms of chronic diseases, specifically heart failure and Alzheimer's disease. By utilizing advanced techniques such as single molecule analysis, live-cell imaging, and genomic and proteomic analysis, the research aims to uncover new insights into disease processes and identify potential drug targets. The approach includes the use of transgenic model animals to study intracellular signaling networks and their roles in disease development. The ultimate goal is to establish new paradigms for clinical therapy and drug screening.
Why it matters
Potential benefit: If successful, this research could lead to novel therapeutic targets and improved treatment options for patients with heart failure and Alzheimer's disease.
How similar studies have gone: Previous research has shown success in understanding signaling pathways in chronic diseases, indicating that this approach has potential for meaningful advancements.
Where this research is happening
-
VA Northern California Health Care Sys
Mather, United States Active
Researchers
- Principal investigator: Xiang, Yang K — VA Northern California Health Care Sys
- Study coordinator: Xiang, Yang K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.