Understanding the mechanisms of frontotemporal lobar degeneration with TDP-43 involvement
Genomics Core
This study is looking into how a protein called TDP-43 might cause frontotemporal lobar degeneration (FTLD), and it's for anyone interested in understanding this condition better, as it could lead to new insights and treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10915042 on NIH RePORTER |
What this research studies
This research focuses on unraveling the mechanisms behind frontotemporal lobar degeneration (FTLD) associated with TDP-43, a protein linked to neurodegenerative diseases. A diverse team of experts in genetics, neuroscience, and pathology will investigate how mis-splicing events caused by TDP-43 dysfunction may initiate the disease process. The project aims to integrate human genetics from the outset and will provide access to high-resolution brain images and data through a web portal, enabling the research community to explore new hypotheses about FTLD. Patients may benefit from advancements in understanding and potential treatments for FTLD-TDP.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals diagnosed with frontotemporal lobar degeneration or related neurodegenerative conditions.
Not a fit: Patients with other forms of dementia not related to frontotemporal lobar degeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with frontotemporal lobar degeneration.
How similar studies have performed: Previous research has shown promise in understanding TDP-43's role in neurodegeneration, indicating that this approach could yield significant insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Raj, Towfique — Stanford University
- Study coordinator: Raj, Towfique
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.