Understanding the mechanisms of frontotemporal lobar degeneration with TDP-43
Human Biomarkers Core
This study is looking into how a protein called TDP-43 causes frontotemporal lobar degeneration, a type of brain disease, and aims to gather helpful information and images of affected brain tissues to better understand the condition and find early signs of it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10915045 on NIH RePORTER |
What this research studies
This research focuses on unraveling the mechanisms behind frontotemporal lobar degeneration with TDP-43 (FTLD-TDP), a neurodegenerative disease. A diverse team of experts in genetics, neuroscience, and pathology will investigate how dysfunction in TDP-43 may lead to disease progression. They aim to create a centralized resource that provides access to detailed data and images of brain tissues affected by FTLD-TDP, which will help in understanding the disease at a cellular level. By integrating human genetics into their approach, they hope to identify early biomarkers and mechanisms of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with frontotemporal lobar degeneration or those exhibiting symptoms related to TDP-43 dysfunction.
Not a fit: Patients with other forms of dementia or neurodegenerative diseases not related to TDP-43 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and targeted therapies for patients with FTLD-TDP.
How similar studies have performed: Previous research has shown promise in understanding neurodegenerative diseases through similar interdisciplinary approaches, indicating potential for success in this novel investigation.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Petrucelli, Leonard — Stanford University
- Study coordinator: Petrucelli, Leonard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.