Understanding the mechanisms of frontotemporal dementia and its link to ALS
Official title: Expanding insights into FTD disease mechanisms
Funded at Mayo Clinic Jacksonville · NIH-10889342 · Data updated 2026-11-12
This study is looking into how frontotemporal lobar degeneration (FTLD) is connected to frontotemporal dementia (FTD) and ALS, with the goal of finding new ways to diagnose and treat these conditions, which could help patients in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | December 15, 2024 |
| Project end | November 30, 2032 |
| Funding year | 2025 |
| Award (this year) | $1,138,538 |
| NIH project number | 1R35NS137447-01 |
| Project ID | NIH-10889342 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals diagnosed with frontotemporal dementia or amyotrophic lateral sclerosis.
✕Less likely to help
Patients with other forms of dementia or neurological disorders unrelated to FTLD or ALS may not receive benefit from this research.
What this research studies
This research investigates the complex mechanisms behind frontotemporal lobar degeneration (FTLD), which is a major cause of frontotemporal dementia (FTD). The study focuses on the genetic and pathological connections between FTLD and amyotrophic lateral sclerosis (ALS), exploring key molecular players such as C9orf72 and TDP-43. By employing innovative techniques and a comprehensive approach, the research aims to identify biomarkers and potential therapies for FTLD, addressing the urgent need for effective treatments. Patients may benefit from insights that could lead to new diagnostic tools and therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to the development of new biomarkers and therapies for frontotemporal dementia and related conditions.
How similar studies have gone: Previous research has shown promising results in understanding the mechanisms of FTLD and ALS, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
-
Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Petrucelli, Leonard — Mayo Clinic Jacksonville
- Study coordinator: Petrucelli, Leonard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.