Understanding the mechanisms of a brain disorder related to ALS and FTD.
Administrative Core
This study is looking into how a protein called TDP-43 might cause problems in the brain that lead to conditions like ALS and frontotemporal dementia, and it's for anyone interested in understanding these diseases better and finding new ways to help.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10915041 on NIH RePORTER |
What this research studies
This research aims to explore the underlying mechanisms of frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP), a condition linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). A diverse team of experts in genetics, neuroscience, and pathology will collaborate to investigate how dysfunction in TDP-43 may lead to mis-splicing events that contribute to the disease. The project will generate and share valuable data and resources, including high-resolution images of human brain samples, to facilitate further research in the field. By integrating human genetics from the outset, the research seeks to provide new insights into the disease process and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with ALS or FTD, as well as those with genetic predispositions to these conditions.
Not a fit: Patients with unrelated neurological disorders or those not diagnosed with ALS or FTD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of ALS and FTD, potentially paving the way for new treatments.
How similar studies have performed: Other research has shown promise in understanding TDP-43's role in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Gitler, Aaron D. — Stanford University
- Study coordinator: Gitler, Aaron D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.