Understanding the mechanisms behind aortic problems in patients with a bicuspid aortic valve.
ROS Mechanisms in BAV Aortopathy
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10870201
This study is looking at how having a bicuspid aortic valve affects the aorta and could lead to serious problems, with the goal of helping doctors better understand and treat patients with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10870201 on ClinicalTrials.gov |
What this research studies
This research investigates the unique biological and biomechanical features of aortic disease associated with bicuspid aortic valves (BAV). It aims to improve patient-specific risk assessments for aortic catastrophes by studying how mechanical and oxidative stress affect the aorta's structure and function. By utilizing advanced imaging techniques and 3D cell culture models, the research seeks to uncover the underlying mechanisms that contribute to aortic aneurysms and dissections in BAV patients. The findings could lead to more tailored treatment guidelines and interventions for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with a bicuspid aortic valve and associated aortic disease.
Not a fit: Patients without a bicuspid aortic valve or those with other unrelated aortic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and treatment strategies for patients with bicuspid aortic valves, potentially reducing the incidence of aortic emergencies.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of aortic disease in similar patient populations, indicating that this approach has potential for success.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GLEASON, THOMAS GILLETTE — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: GLEASON, THOMAS GILLETTE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.