Understanding the mechanics of right ventricular failure
Multiscale mechanobiology of right ventricular failure
This study is looking into what causes right ventricular failure (RVF) by using advanced computer models to understand how problems in the heart happen, with the goal of finding better treatments for people who have this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10911832 on NIH RePORTER |
What this research studies
This research investigates the complex factors contributing to right ventricular failure (RVF) using advanced computational modeling techniques. By analyzing dysfunction at various biological scales—from cellular components to whole organ systems—the study aims to identify the underlying mechanisms of RVF. The approach integrates data from healthy and affected tissues to predict how these dysfunctions manifest in patients. Ultimately, this research seeks to pave the way for developing targeted therapies for RVF, which currently lacks specific treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 21 years old who are experiencing symptoms of right ventricular failure or related cardiac dysfunction.
Not a fit: Patients with left ventricular failure or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies specifically designed for patients suffering from right ventricular failure.
How similar studies have performed: While research on left ventricular failure has shown success with similar computational modeling approaches, studies specifically targeting right ventricular failure are less common and represent a novel area of investigation.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Chesler, Naomi C — University of California-Irvine
- Study coordinator: Chesler, Naomi C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.