Understanding the mechanical relationship between the optic nerve head and surrounding tissue in glaucoma.
Official title: Biomechanical Interplay between Optic Nerve Head and Peripapillary Sclera
Funded at Ohio State University · NIH-10912514 · Data updated 2026-11-12
This study is looking at how pressure in the eye affects the optic nerve in people with glaucoma, with the hope of finding new ways to help those who are still losing their vision even with current treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 30, 2022 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $324,604 |
| NIH project number | 5R01EY032621-03 |
| Project ID | NIH-10912514 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults, particularly those aged 65 and older, and individuals of African American descent who are at higher risk for glaucoma.
✕Less likely to help
Patients with glaucoma who are younger than 65 or do not have risk factors such as high myopia or African American ethnicity may not benefit from this research.
What this research studies
This research investigates how mechanical forces at the optic nerve head (ONH) contribute to glaucoma, a leading cause of blindness. By using advanced ultrasound elastography, the study aims to measure the biomechanical properties of the peripapillary sclera (PPS) and how they interact with the ONH under different conditions. The goal is to identify modifiable risk factors that could lead to new treatments for glaucoma, especially for patients who continue to experience vision loss despite current therapies.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that better protect against vision loss in glaucoma patients.
How similar studies have gone: While the approach of using ultrasound elastography in this context is relatively novel, similar biomechanical studies have shown promise in understanding other ocular conditions.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Liu, Jun — Ohio State University
- Study coordinator: Liu, Jun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.