Understanding the mechanical relationship between the optic nerve and surrounding tissue in glaucoma patients
Biomechanical interplay between optic nerve head and peripapillary sclera
This study is looking at how pressure and movement in the eye affect the optic nerve and surrounding tissues in people with glaucoma, especially older adults and those at higher risk, to find new ways to help protect their vision.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10995732 on NIH RePORTER |
What this research studies
This research investigates how mechanical forces affect the optic nerve head and the surrounding peripapillary sclera in patients with glaucoma. By utilizing advanced 3-D ultrasound elastography, the study aims to measure the biomechanical properties of these tissues, particularly in older adults and those at higher risk for glaucoma. The goal is to identify modifiable factors that could lead to new treatment strategies for preserving vision in glaucoma patients. This approach seeks to fill existing knowledge gaps regarding how these mechanical interactions contribute to optic nerve damage.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults, particularly those over 65 years of age, and individuals at higher risk for glaucoma, such as African Americans and those with high myopia.
Not a fit: Patients who are not diagnosed with glaucoma or do not have risk factors associated with the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that better protect vision in glaucoma patients by addressing underlying mechanical factors.
How similar studies have performed: While the biomechanical aspects of glaucoma are being explored, this specific approach using high-resolution ultrasound elastography is relatively novel and has not been extensively tested in previous studies.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Liu, Jun — Ohio State University
- Study coordinator: Liu, Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.