Understanding the mechanical factors that lead to kidney cyst formation
Biomechanical drivers of cystogenesis
This study is looking at how the way kidney cells communicate and respond to their environment might cause cysts to form in people with autosomal dominant polycystic kidney disease (ADPKD), with the hope of finding new ways to prevent or treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10891647 on NIH RePORTER |
What this research studies
This research investigates how mechanical signals and interactions between kidney cells contribute to the formation of cysts in autosomal dominant polycystic kidney disease (ADPKD). By examining the role of cell polarization and the extracellular matrix, the study aims to uncover the biomechanical imbalances that lead to tubular malformations. The researchers will utilize both experimental and computational methods to analyze these processes, potentially identifying new therapeutic targets for preventing or reversing cystogenesis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autosomal dominant polycystic kidney disease.
Not a fit: Patients without a diagnosis of polycystic kidney disease or those with other unrelated kidney conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce kidney cyst formation in patients with ADPKD.
How similar studies have performed: While the specific biomechanical approach to cystogenesis is novel, related research has shown promise in understanding kidney diseases through mechanobiological studies.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Gusella, Gabriele Luca — Icahn School of Medicine at Mount Sinai
- Study coordinator: Gusella, Gabriele Luca
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.