Understanding the link between knee damage and pain in osteoarthritis
Official title: Unraveling the discordance between structural damage and pain phenotypes in knee osteoarthritis
Funded at Massachusetts General Hospital · NIH-10949617 · Data updated 2026-11-12
This study is looking at how different kinds of pain in people with knee osteoarthritis are connected to the damage seen in imaging tests, like MRIs, to help find better ways to manage pain and improve treatments for knee issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $174,689 |
| NIH project number | 1K23AR084603-01 |
| Project ID | NIH-10949617 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are experiencing knee osteoarthritis.
✕Less likely to help
Patients with knee pain not related to osteoarthritis or those under 21 years old may not benefit from this research.
What this research studies
This research investigates how different types of pain in knee osteoarthritis (KOA) relate to structural damage seen in imaging tests like MRI and CT scans. It aims to identify specific pain phenotypes, such as nociceptive and neuropathic-like pain, and how these relate to imaging biomarkers. By examining these relationships, the research seeks to improve clinical management and develop better treatments for KOA. Patients may be followed for six months post knee replacement to assess persistent pain.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and management strategies for patients suffering from knee osteoarthritis.
How similar studies have gone: Previous research has shown promise in understanding pain mechanisms in osteoarthritis, making this approach both relevant and potentially impactful.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Jarraya, Mohamed — Massachusetts General Hospital
- Study coordinator: Jarraya, Mohamed
Related research
Other NIH-funded projects on the same topics.
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Aims to map inflammation across the body and brain in people with knee osteoarthritis using advanced imaging to help explain and improve pain and treatment.
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Determinants of rapid knee osteoarthritis progression using radiograph features
A patient-friendly look at how knees with osteoarthritis may progress more quickly, using advanced X-ray measurements to identify who is at higher risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.