Understanding the link between knee damage and pain in osteoarthritis
Unraveling the discordance between structural damage and pain phenotypes in knee osteoarthritis
['FUNDING_OTHER'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10949617
This study is looking at how different kinds of pain in people with knee osteoarthritis are connected to the damage seen in imaging tests, like MRIs, to help find better ways to manage pain and improve treatments for knee issues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10949617 on ClinicalTrials.gov |
What this research studies
This research investigates how different types of pain in knee osteoarthritis (KOA) relate to structural damage seen in imaging tests like MRI and CT scans. It aims to identify specific pain phenotypes, such as nociceptive and neuropathic-like pain, and how these relate to imaging biomarkers. By examining these relationships, the research seeks to improve clinical management and develop better treatments for KOA. Patients may be followed for six months post knee replacement to assess persistent pain.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing knee osteoarthritis.
Not a fit: Patients with knee pain not related to osteoarthritis or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and management strategies for patients suffering from knee osteoarthritis.
How similar studies have performed: Previous research has shown promise in understanding pain mechanisms in osteoarthritis, making this approach both relevant and potentially impactful.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JARRAYA, MOHAMED — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: JARRAYA, MOHAMED
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.