Understanding the link between blood clotting and inflammation in placental abruption
Official title: Coagulation-inflammation crosstalk in placental abruption
Funded at Medical College of Wisconsin · NIH-10909023 · Data updated 2026-11-12
This study is looking at how blood clotting and inflammation work together in cases of placental abruption, a serious issue during pregnancy, to help find early warning signs and possible treatments for expecting moms and their babies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | August 20, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $587,641 |
| NIH project number | 5R01HL163623-02 |
| Project ID | NIH-10909023 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant individuals who may be at risk for placental abruption or have experienced complications related to this condition.
✕Less likely to help
Patients who are not pregnant or those who have no history of placental issues are unlikely to benefit from this research.
What this research studies
This research investigates how blood coagulation and inflammation interact in cases of placental abruption, a serious pregnancy complication. By using animal models, the study aims to uncover the mechanisms that lead to this condition, particularly focusing on the role of specific proteins and inflammatory responses. The researchers will analyze how these processes contribute to the separation of the placenta from the uterus, which can endanger both the mother and baby. Insights gained from this research could help identify early warning signs and potential interventions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of placental abruption, potentially reducing risks for mothers and their babies.
How similar studies have gone: Previous studies have shown promising results in understanding the mechanisms of placental complications through similar approaches, indicating potential for success in this research.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Sood, Rashmi — Medical College of Wisconsin
- Study coordinator: Sood, Rashmi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.