Understanding the Ksr2 Gene in Obesity, Type 2 Diabetes, and Bone Health
Official title: Role and Mechanism of Action of Ksr2, an Obesity and Type 2 Diabetes Gene, in Bone Metabolism
Funded at Loma Linda Veterans Assn Research & Educ · NIH-10996176 · Data updated 2026-11-12
This research explores how a specific gene, Ksr2, connects obesity and type 2 diabetes with bone health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loma Linda Veterans Assn Research & Educ NIH-funded |
| Lab location | 1 site (Redlands, United States) |
| Project start | January 1, 2003 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $312,631 |
| NIH project number | 5R01AR048139-16 |
| Project ID | NIH-10996176 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research does not directly involve patient participation at this stage, but future studies stemming from it may seek individuals with obesity, type 2 diabetes, and bone health concerns.
✕Less likely to help
Patients not affected by obesity, type 2 diabetes, or related bone issues would not directly benefit from this specific line of research.
What this research studies
Many people face challenges with obesity, type 2 diabetes, and bone fractures as they get older. While obese and diabetic individuals often have higher bone density, they also experience more fractures, and these fractures can be more severe. This project aims to uncover why this happens by focusing on a gene called Ksr2, which has been linked to obesity and type 2 diabetes. By understanding how Ksr2 works, we hope to find new ways to protect bone health in people with these conditions.
Why it matters
Potential benefit: If successful, this work could lead to new treatments or prevention strategies for bone fractures in individuals living with obesity and type 2 diabetes.
How similar studies have gone: The discovery of Ksr2's effect on bone mass in animal models is a novel finding that builds upon existing knowledge of its role in obesity and type 2 diabetes.
Where this research is happening
-
Loma Linda Veterans Assn Research & Educ
Redlands, United States Active
Researchers
- Principal investigator: Mohan, Subburaman — Loma Linda Veterans Assn Research & Educ
- Study coordinator: Mohan, Subburaman
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.