Understanding the junctions between lens fiber cells and their role in eye health
Official title: Characterization of the lens fiber cell tricellular junctional complex and its dependency on delta-catenin
Funded at Ohio State University · NIH-10738883 · Data updated 2026-11-12
This study is looking at how special connections between cells in the eye's lens help keep it clear and healthy, focusing on a protein called delta-catenin, which could help us understand cataracts better and improve eye health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 30, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $433,125 |
| NIH project number | 1R21EY034213-01A1 |
| Project ID | NIH-10738883 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of cataracts or those experiencing early signs of lens opacity.
✕Less likely to help
Patients with cataracts caused by trauma or other non-genetic factors may not benefit from this research.
What this research studies
This research investigates the unique junctions formed between lens fiber cells in the eye, focusing on a specific protein called delta-catenin that is crucial for maintaining these junctions. By examining how these junctions contribute to the organization and transparency of the lens, the study aims to uncover new insights into eye health and potential cataract formation. The research employs advanced proteomic techniques to identify the proteins involved in these junctions and their interactions, which could lead to a better understanding of lens biology and associated diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cataracts and other lens-related disorders.
How similar studies have gone: Previous research has shown that understanding cellular junctions can lead to breakthroughs in treating various eye conditions, suggesting this approach has potential for success.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Plageman, Timothy F — Ohio State University
- Study coordinator: Plageman, Timothy F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.