Understanding the interaction of proteins in Lewy body dementia
Synergistic Interaction of amyloid-beta and alpha-synuclein in Lewy body Dementia
This study is looking at how certain proteins in the brain might work together to cause Lewy body dementia, especially in people who have a specific genetic risk factor, and it will use brain tissue samples to help understand these connections better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project ID | NIH-10686893 on NIH RePORTER |
What this research studies
This research investigates how amyloid-beta and alpha-synuclein proteins interact and contribute to Lewy body dementia (LBD), particularly focusing on genetic risk factors like apolipoprotein E4. Researchers will analyze postmortem brain tissue from the Mayo Clinic Brain Bank to explore various biological aspects, including genetics, protein interactions, and lipid profiles. The study aims to uncover the underlying mechanisms of LBD through advanced techniques in neuropathology and biochemistry, involving multiple research projects led by experienced investigators.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Lewy body dementia or those with genetic predispositions to the condition.
Not a fit: Patients without Lewy body dementia or those not carrying genetic risk factors for the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential new treatments for Lewy body dementia.
How similar studies have performed: Previous research has shown promising results in understanding protein interactions in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Jacksonville, United States
- Mayo Clinic Jacksonville — Jacksonville, United States (Active)
Researchers
- Principal investigator: Dickson, Dennis William — Mayo Clinic Jacksonville
- Study coordinator: Dickson, Dennis William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.