Understanding the impact of multiple brain pathologies on aging and Alzheimer's disease.
Official title: Core A: Administrative Core
Funded at Columbia University Health Sciences · NIH-10935933 · Data updated 2026-11-12
This study is looking at how different health issues impact the aging brain, especially in people with Alzheimer's disease, to help us better understand and treat the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 30, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $625,518 |
| NIH project number | 5U19AG074862-02 |
| Project ID | NIH-10935933 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals diagnosed with Alzheimer's disease or those experiencing cognitive decline associated with aging.
✕Less likely to help
Patients with early-stage cognitive impairment or those without any neurological conditions may not receive direct benefits from this research.
What this research studies
This research focuses on exploring how various pathologies affect the aging brain, particularly in the context of Alzheimer's disease. By utilizing advanced techniques that combine single-cell analysis with spatially-resolved transcriptomic and proteomic measurements, the program aims to create a detailed three-dimensional understanding of brain changes. The project is organized into multiple cores and research projects, all coordinated by an Administrative Core to ensure effective oversight and communication. Patients may benefit from insights gained through this research that could lead to improved understanding and treatment of Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic and therapeutic strategies for Alzheimer's disease and related conditions.
How similar studies have gone: Previous research has shown promise in using advanced imaging and molecular techniques to study Alzheimer's disease, indicating that this approach may yield valuable insights.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: De Jager, Philip L — Columbia University Health Sciences
- Study coordinator: De Jager, Philip L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.