Understanding the impact of HIV and STIs on mothers and infants in Botswana.
Modeling the Effects of HIV, Chlamydia, and Gonorrhea in Mother-Infant Pairs in Botswana.
This study looks at how HIV, chlamydia, and gonorrhea can affect the health of mothers and their babies in Botswana, and it wants to find out if regular testing for these infections during pregnancy can help prevent serious problems like stillbirth and neonatal death.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10789879 on NIH RePORTER |
What this research studies
This research investigates the effects of HIV, chlamydia, and gonorrhea on birth outcomes in mother-infant pairs in Botswana. It aims to model the risks associated with these infections during pregnancy, particularly focusing on adverse outcomes like stillbirth and neonatal death. The study seeks to evaluate the effectiveness of antenatal screening for these STIs, which is not routinely practiced in sub-Saharan Africa, compared to the current symptom-driven treatment approach. By utilizing simulation modeling, the research aims to provide insights that could improve maternal and infant health in resource-limited settings.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant women living with HIV in Botswana who may also be at risk for chlamydia and gonorrhea.
Not a fit: Patients who are not pregnant or those who do not have HIV or STIs may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved screening and treatment protocols for pregnant women with HIV, ultimately reducing adverse birth outcomes.
How similar studies have performed: Previous research has shown that antenatal screening for STIs can significantly improve health outcomes in high-income settings, suggesting potential for success in similar approaches in resource-limited environments.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Dugdale, Caitlin — Massachusetts General Hospital
- Study coordinator: Dugdale, Caitlin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.