Understanding the impact of bisphosphonates on fractures in patients with peripheral arterial disease
Calculator for Length of Use of Bisphosphonates (CLUB) - Diversity Supplement
This study looks at how a medication called bisphosphonates might help reduce the risk of fractures in older adults, both with and without a condition called peripheral arterial disease (PAD), to find better ways to treat osteoporosis and keep you healthier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project ID | NIH-11198105 on NIH RePORTER |
What this research studies
This research investigates how bisphosphonate therapy affects the risk of fractures in older adults with and without peripheral arterial disease (PAD). By analyzing data from the Veterans Health Administration, the study aims to determine the incidence of clinical fractures, particularly in the lower extremities, among patients receiving bisphosphonates. Additionally, it will assess the mortality and morbidity associated with fractures in these patients over time. This research seeks to provide insights that could improve treatment strategies for osteoporosis in individuals with PAD.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are receiving bisphosphonate therapy and have either been diagnosed with peripheral arterial disease or are at risk for it.
Not a fit: Patients who are not on bisphosphonate therapy or do not have osteoporosis or peripheral arterial disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better management of osteoporosis in patients with peripheral arterial disease, potentially reducing fracture rates and improving overall health outcomes.
How similar studies have performed: Previous studies have indicated a relationship between cardiovascular disease and osteoporosis, suggesting that this research could build on established findings, although the specific focus on PAD and bisphosphonates is relatively novel.
Where this research is happening
Augusta, United States
- Augusta University — Augusta, United States (Active)
Researchers
- Principal investigator: Carbone, Laura D — Augusta University
- Study coordinator: Carbone, Laura D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.