Understanding the Immune System's Role in Alzheimer's Disease
The Role of the Complement Pathway in Alzheimer's Disease
This project explores how a part of our immune system contributes to Alzheimer's disease by affecting brain cells called microglia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11162503 on NIH RePORTER |
What this research studies
We know that in Alzheimer's disease, certain brain cells called microglia become overactive and inflamed around harmful protein clumps. These microglia usually help clear away these clumps, but they can become less effective over time. This research looks at a specific part of the immune system, called the complement pathway, which seems to play a role in this microglial dysfunction. By understanding how this pathway affects microglia's ability to process energy and clear harmful proteins, we hope to find new ways to protect brain health.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals living with or at risk for Alzheimer's disease.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could identify new targets for therapies that restore healthy microglial function and slow or prevent the progression of Alzheimer's disease.
How similar studies have performed: Previous genetic studies have highlighted the importance of microglia in Alzheimer's, and other research suggests that inhibiting the complement pathway may offer protection against the disease.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Zheng, Hui — Baylor College of Medicine
- Study coordinator: Zheng, Hui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.