Understanding the immune system in salivary glands against a common virus
Immune response to MCMV infection in the salivary glands
['FUNDING_R01'] · BROWN UNIVERSITY · NIH-11124041
This work explores how our immune system fights off a common virus, similar to human cytomegalovirus, within the salivary glands.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BROWN UNIVERSITY (nih funded) |
| Locations | 1 site (PROVIDENCE, UNITED STATES) |
| Trial ID | NIH-11124041 on ClinicalTrials.gov |
What this research studies
Human cytomegalovirus (HCMV) is a very common virus that stays in the body for life, often without symptoms in healthy people but causing serious problems for pregnant women, newborns, and those with weakened immune systems. This project uses a mouse version of HCMV to understand why the virus can hide and persist in the salivary glands. We are looking at how immune cells, like NK cells, behave in the salivary glands and how the local environment might prevent them from fully clearing the virus. By understanding these immune responses, we hope to find new ways to help the body fight off persistent viral infections.
Who could benefit from this research
Good fit: This foundational work could eventually benefit patients who are immunocompromised, pregnant, or neonates affected by human cytomegalovirus.
Not a fit: Patients seeking immediate treatment or direct clinical participation will not find benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for treating or preventing persistent viral infections like HCMV, especially for vulnerable patients.
How similar studies have performed: This project builds on existing knowledge of the mouse cytomegalovirus model and includes preliminary data, suggesting a solid foundation for its novel approach.
Where this research is happening
PROVIDENCE, UNITED STATES
- BROWN UNIVERSITY — PROVIDENCE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BROSSAY, LAURENT — BROWN UNIVERSITY
- Study coordinator: BROSSAY, LAURENT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.