Understanding the immune response to Clostridioides difficile infection
CORE 1: The Clinical Data and Biospecimen Repository Core
This study is looking at how your immune system responds to Clostridioides difficile infection (CDI) by collecting stool and blood samples from people diagnosed with CDI, so we can learn more and find better ways to treat and prevent it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11044215 on NIH RePORTER |
What this research studies
This research focuses on Clostridioides difficile infection (CDI), a leading cause of antibiotic-associated diarrhea. It aims to evaluate the immune response to CDI by collecting patient biospecimens and clinical data from individuals diagnosed with the infection. Patients will be recruited from a large medical center, where trained personnel will gather stool samples and blood at various intervals after diagnosis. The goal is to enhance understanding of the immune response to CDI and improve future treatment and prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals of all ages diagnosed with Clostridioides difficile infection.
Not a fit: Patients who do not have Clostridioides difficile infection or those who are not willing to provide biospecimens may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatments and vaccines for Clostridioides difficile infection, reducing recurrence rates and improving patient outcomes.
How similar studies have performed: Previous research has shown promise in understanding immune responses to infections, but this specific approach to CDI is relatively novel.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Nicholson, Maribeth Ruth — Vanderbilt University Medical Center
- Study coordinator: Nicholson, Maribeth Ruth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.