Understanding the immune response in tuberculosis lung infections
Dynamics of the cellular and molecular architecture of human pulmonary TB granulomas
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11009019
This study is looking at how different immune cells in the lungs of people with tuberculosis work together, which could help us understand why some patients get better while others struggle with the disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11009019 on ClinicalTrials.gov |
What this research studies
This research investigates how different immune cells interact within the granulomas formed in the lungs of patients with tuberculosis (TB). By using advanced techniques like single cell RNA sequencing, the study aims to map the various cell types and their roles in fighting the TB bacteria. The researchers will explore how certain immune cells, particularly macrophages and T cells, contribute to either controlling the infection or worsening the disease. This work could provide insights into why some patients respond well to treatment while others do not.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary tuberculosis.
Not a fit: Patients with latent TB infection or those without active pulmonary disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for tuberculosis by identifying new targets for therapy.
How similar studies have performed: Previous research has shown success in understanding immune responses in other infectious diseases, suggesting that this approach may yield valuable insights for tuberculosis as well.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MODLIN, ROBERT L — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: MODLIN, ROBERT L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.