Understanding the immune response in monkeys to improve HIV vaccines
Population genotyping of the germline immunoglobulin repertoire in AIDS-designated rhesus macaque breeding colonies
This study is looking at how the immune systems of rhesus macaques fight HIV by examining their antibodies, which could help scientists create better vaccines for people living with HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10812487 on NIH RePORTER |
What this research studies
This research focuses on studying the genetic makeup of antibodies in rhesus macaques to better understand how their immune systems respond to HIV. By analyzing the evolution of these antibodies over time, researchers aim to identify patterns that could lead to the development of effective vaccines. The study utilizes advanced sequencing techniques to track genetic changes and employs bioinformatics to infer the original antibody sequences. This approach is crucial for discovering broadly neutralizing antibodies that can combat various strains of HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are involved in HIV vaccine trials or those interested in the genetic aspects of immune responses to HIV.
Not a fit: Patients who are not involved in HIV research or do not have a connection to HIV vaccine development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective HIV vaccines that provide better protection for patients.
How similar studies have performed: Previous research has shown promise in using similar genetic and bioinformatics approaches to understand immune responses, indicating potential for success in this area.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Bosinger, Steven Edward — Emory University
- Study coordinator: Bosinger, Steven Edward
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.