Understanding the immune response in early colorectal cancer lesions
The immune contexture of colorectal adenomas and serrated polyps
This study is looking at how the immune system responds to early signs of colorectal cancer, like certain types of polyps, to see if these responses can affect whether these polyps turn into cancer, while also considering how personal habits and lifestyle choices might play a role.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-10669206 on NIH RePORTER |
What this research studies
This research investigates how the immune system interacts with early colorectal cancer lesions, specifically tubular adenomas, tubulovillous adenomas, and sessile serrated polyps. By analyzing biospecimens and data from previous studies, the research aims to determine how different immune responses may influence the progression of these lesions to invasive cancer. The study will also explore how personal and lifestyle factors affect these immune responses, providing a comprehensive view of the immune contexture in colorectal neoplasia.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of colorectal adenomas or serrated polyps.
Not a fit: Patients without any history of colorectal lesions or those with advanced colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing colorectal cancer by targeting immune responses in early lesions.
How similar studies have performed: While there is preliminary data on immune responses in colorectal cancer, this research aims to fill significant gaps and is considered novel in its approach.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Wallace, Kristin — Medical University of South Carolina
- Study coordinator: Wallace, Kristin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.