Understanding the human DNA virome and its interactions with host cells
The Human DNA virome: from petabase scale to single-cell resolution
This study is looking at how certain DNA viruses in our bodies interact with our cells, especially in people aged 65 and older, to help us understand how these viruses might affect health as we age.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10987464 on NIH RePORTER |
What this research studies
This research investigates the human virome, focusing on DNA viruses present in human tissues and how they interact with host cells. By utilizing advanced sequencing technologies, the project aims to analyze vast amounts of genetic data to uncover the presence of latent viral DNA in individuals, particularly those aged 65 and older. The study will employ innovative computational and experimental methods to characterize these viral features and their relationship with human genetics and cellular responses. Patients may benefit from insights into how viral infections can affect health, especially in older populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who may have latent viral infections.
Not a fit: Patients younger than 65 years old or those without any viral infections may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of viral infections and their implications for health in older adults.
How similar studies have performed: Other research has shown promise in understanding viral interactions using advanced sequencing techniques, indicating potential for success in this novel approach.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Lareau, Caleb Andrew — Sloan-Kettering Inst Can Research
- Study coordinator: Lareau, Caleb Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.