Understanding the human DNA virome and its interactions with host cells
Official title: The Human DNA virome: from petabase scale to single-cell resolution
Funded at Sloan-Kettering Inst Can Research · NIH-10987464 · Data updated 2026-11-12
This study is looking at how certain DNA viruses in our bodies interact with our cells, especially in people aged 65 and older, to help us understand how these viruses might affect health as we age.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 20, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $1,061,833 |
| NIH project number | 1U01AT012984-01 |
| Project ID | NIH-10987464 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who may have latent viral infections.
✕Less likely to help
Patients younger than 65 years old or those without any viral infections may not receive benefit from this research.
What this research studies
This research investigates the human virome, focusing on DNA viruses present in human tissues and how they interact with host cells. By utilizing advanced sequencing technologies, the project aims to analyze vast amounts of genetic data to uncover the presence of latent viral DNA in individuals, particularly those aged 65 and older. The study will employ innovative computational and experimental methods to characterize these viral features and their relationship with human genetics and cellular responses. Patients may benefit from insights into how viral infections can affect health, especially in older populations.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of viral infections and their implications for health in older adults.
How similar studies have gone: Other research has shown promise in understanding viral interactions using advanced sequencing techniques, indicating potential for success in this novel approach.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Lareau, Caleb Andrew — Sloan-Kettering Inst Can Research
- Study coordinator: Lareau, Caleb Andrew
Related research
Other NIH-funded projects on the same topics.
-
Understand how skeletal muscle nuclei specialize and arrange themselves for proper muscle function
A study to uncover how the hundreds of nuclei in skeletal muscle fibers acquire different roles and positions to keep muscles strong and healthy.
-
Genomic profiling and outcomes of cancers in World Trade Center-exposed survivors and responders
This project looks at the genetic makeup and real-world cancer outcomes in people exposed to the World Trade Center disaster to understand how their cancers behave and respond to treatments.
-
Meaning-Centered Psychotherapy for Mexican Patients with Advanced Cancer
A cancer center in Mexico will test a culturally adapted therapy to help Mexican patients with advanced cancer find meaning, peace, and purpose at the end of life.
-
High-specificity genome-scale cell-surface proteomics to find tumor targets
A cancer research project is trying to map all the proteins on the surface of ultra-rare sarcoma cells to find safe, targeted ways to treat them.
-
Priorities for testing and choosing combination therapies in rhabdoid tumors to guide clinical trials
A coordinated, multi-site effort will rigorously test promising drug combinations in rhabdoid tumors to identify the most promising options for future patient trials.
-
ecDNA in Cancer: Understanding and targeting circular DNA that drives tumor growth
A cancer-focused project to understand how extrachromosomal DNA helps tumors grow and resist treatment, and to develop new ways to target these mechanisms.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.