Understanding the HIV reservoir in the body
Single-Cell Analysis of the HIV/SIV Reservoir
This study is looking at how certain immune cells in people with HIV can hide the virus, making it hard to find a cure, and it aims to learn more about these hidden cells so that better treatments can be developed.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10852855 on NIH RePORTER |
What this research studies
This research investigates the viral reservoir in latently infected CD4+ T lymphocytes, which is a major barrier to curing HIV. By utilizing advanced single-cell genomic profiling techniques, the study aims to identify the different cellular subsets that make up this reservoir and their characteristics. The research involves collaboration between experts in HIV cure studies and genomic profiling, focusing on how certain immune strategies can target these reservoir cells. The ultimate goal is to enhance our understanding of the viral reservoir to develop more effective HIV cure strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are interested in novel therapeutic approaches and have previously undergone antiretroviral therapy.
Not a fit: Patients who are not living with HIV or those who are not responsive to antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies that may help achieve a functional cure for HIV.
How similar studies have performed: Previous research has shown promise in targeting the HIV reservoir using immunotherapeutic strategies, indicating potential for success in this approach.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Barouch, Dan H. — Beth Israel Deaconess Medical Center
- Study coordinator: Barouch, Dan H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.