Understanding the HIV-1 virus and its interactions for better treatments and vaccines
Official title: Multiscale Computational Microscopy of HIV-1
Funded at University of California, San Diego · NIH-10884393 · Data updated 2026-11-12
This study is looking at how the HIV-1 virus interacts with human cells to help create better vaccines and find new treatments for people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | July 7, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $661,893 |
| NIH project number | 5R01AI179188-02 |
| Project ID | NIH-10884393 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV or those at high risk of HIV infection who are seeking new treatment options.
✕Less likely to help
Patients who are not affected by HIV or those who have already achieved viral suppression may not benefit directly from this research.
What this research studies
This research investigates the HIV-1 virus, which causes AIDS, by using advanced computational techniques to simulate the virus's envelope protein and its interactions with human cells. By employing all-atom molecular dynamics simulations, the team aims to uncover details about the virus's structure and behavior that are not visible through traditional experimental methods. This approach will help in designing better vaccines and identifying potential drug targets to combat HIV-1 effectively.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccines and treatments for HIV-1, ultimately reducing infection rates and improving patient outcomes.
How similar studies have gone: Previous research using computational modeling has shown promise in understanding viral structures and developing vaccines, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Amaro, Rommie E — University of California, San Diego
- Study coordinator: Amaro, Rommie E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.