Understanding the history of cell behavior through gene activity
Official title: Genome-wide assessment of transcriptional state history
Funded at University of Colorado Denver · NIH-11128771 · Data updated 2026-11-12
This study is looking at how cells change and behave over time by examining their genes, which could help us understand diseases like cancer better and find new ways to treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | July 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $390,000 |
| NIH project number | 5R01HG013472-02 |
| Project ID | NIH-11128771 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with conditions that involve significant cellular changes, such as cancer patients.
✕Less likely to help
Patients with stable, non-progressive conditions that do not involve cellular changes may not benefit from this research.
What this research studies
This research investigates how cells change over time by analyzing their gene activity. It aims to create a comprehensive record of a cell's transcriptional history, which is crucial for understanding how cells function in health and disease. By using advanced technologies like next-generation sequencing, the study will track the lineage and past states of cells, providing insights that current methods cannot achieve. This could lead to better treatment strategies for various conditions, particularly in cancer.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments by providing deeper insights into how cells behave and adapt over time.
How similar studies have gone: Other research has shown promise in using advanced sequencing technologies to understand cellular behavior, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Breuss, Martin Werner — University of Colorado Denver
- Study coordinator: Breuss, Martin Werner
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.