Understanding the hidden HIV reservoir in patients
Phenotypic and mechanistic analysis of the in vivo HIV latent reservoir by single-cell technologies
This study is looking at hidden HIV cells in people living with HIV to understand how they work and respond to treatments, with the hope of finding ways to get rid of these cells so that people can manage their HIV without needing ongoing treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10448398 on NIH RePORTER |
What this research studies
This research investigates the latent HIV reservoir in individuals living with HIV, which is a major barrier to achieving a cure. By using advanced single-cell technologies, the study aims to characterize the properties of latently-infected cells without altering their natural state. This involves analyzing patient-derived cells to better understand how these cells behave and respond to treatment. The ultimate goal is to find ways to eliminate or control this reservoir, potentially allowing for treatment-free management of HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy.
Not a fit: Patients who are not living with HIV or those who have never been on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for eliminating the HIV reservoir, reducing the need for lifelong antiretroviral therapy.
How similar studies have performed: Other research has shown promise in characterizing HIV reservoirs using advanced single-cell technologies, indicating that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- J. David Gladstone Institutes — San Francisco, United States (Active)
Researchers
- Principal investigator: Roan, Nadia R — J. David Gladstone Institutes
- Study coordinator: Roan, Nadia R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.