Understanding the genetics of schizophrenia in the Xhosa people of South Africa
2/3 Genomics of Schizophrenia in the South African Xhosa
This study is looking at how genes might play a role in schizophrenia among the Xhosa people in South Africa, and it's inviting 1250 individuals with schizophrenia and 1250 people without it to help find out more about the genetic differences that could affect mental health, which could lead to better treatments down the line.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11085137 on NIH RePORTER |
What this research studies
This research aims to explore the genetic factors contributing to schizophrenia specifically within the Xhosa population in South Africa. By enrolling 1250 individuals diagnosed with schizophrenia and 1250 matched controls, the study will analyze genetic variations that may influence the condition. The research utilizes advanced genomic techniques to identify rare mutations that could be linked to the disorder, enhancing our understanding of how genetics affects mental health in this unique population. Participants will contribute to a larger effort to uncover the genetic architecture of schizophrenia, which may lead to more targeted treatments in the future.
Who could benefit from this research
Good fit: Ideal candidates for participation are Xhosa-speaking individuals diagnosed with schizophrenia or those who are age- and gender-matched controls.
Not a fit: Patients who do not identify as Xhosa or do not have a diagnosis of schizophrenia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for schizophrenia, particularly for individuals of African descent.
How similar studies have performed: Previous research has shown success in identifying genetic factors in schizophrenia within diverse populations, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Susser, Ezra S. — Columbia University Health Sciences
- Study coordinator: Susser, Ezra S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.