Understanding the genetics of PTSD in people of African descent
Official title: Genetics of PTSD in African Ancestry Populations: Enhancing discovery by addressing inequality
Funded at Broad Institute, INC. · NIH-10914252 · Data updated 2026-11-12
This study is looking at how genes might affect the risk of PTSD in people with African ancestry, and it aims to include those communities in the research to make sure the results are helpful for everyone involved.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | August 25, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $2,000,057 |
| NIH project number | 5R01MH134468-02 |
| Project ID | NIH-10914252 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include individuals of African ancestry who have experienced trauma and may be at risk for PTSD.
✕Less likely to help
Patients who do not have African ancestry or those who have not experienced trauma may not benefit from this research.
What this research studies
This research aims to uncover the genetic factors associated with PTSD specifically in African ancestry populations. By collaborating with African investigators and utilizing large genetic datasets, the project seeks to identify genetic variants that contribute to PTSD risk. The study will also address the historical underrepresentation of African populations in genetic research, ensuring that findings are relevant and beneficial to these communities. Patients may be involved in genetic data collection and analysis to enhance understanding of PTSD.
Why it matters
Potential benefit: If successful, this research could lead to more accurate risk assessments and targeted treatments for PTSD in individuals of African descent.
How similar studies have gone: Previous research has shown success in genetic studies of PTSD, but this approach focusing on African populations is novel and aims to fill a critical gap in the field.
Where this research is happening
-
Broad Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Koenen, Karestan C — Broad Institute, INC.
- Study coordinator: Koenen, Karestan C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.