Understanding the genetics of osteoarthritis and improving recovery after joint replacement
Official title: Genetics of Osteoarthritis and Joint Replacement Recovery: Key to Precision Rehabilitation
Funded at Birmingham VA Medical Center · NIH-10851739 · Data updated 2026-11-12
This study is looking at how your genes might affect your recovery after joint replacement surgery for osteoarthritis, especially for veterans, so we can create better, personalized rehab plans that work for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Birmingham VA Medical Center NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| NIH project number | 5I01RX002745-07 |
| Project ID | NIH-10851739 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include veterans suffering from end-stage osteoarthritis who are scheduled for total hip or knee arthroplasty.
✕Less likely to help
Patients who do not have osteoarthritis or are not veterans may not receive any benefit from this research.
What this research studies
This research investigates the genetic factors contributing to osteoarthritis (OA) and how these factors can influence recovery after joint replacement surgeries, specifically in veterans. By analyzing data from a large cohort of veterans, the study aims to identify genetic markers that may predict rehabilitation outcomes. The goal is to develop personalized rehabilitation strategies that cater to the unique genetic backgrounds of patients, particularly focusing on diverse populations such as African American and Hispanic veterans. This approach seeks to enhance the quality of life for those affected by OA and improve their post-surgical recovery.
Why it matters
Potential benefit: If successful, this research could lead to tailored rehabilitation programs that significantly improve recovery outcomes for patients undergoing joint replacement surgery.
How similar studies have gone: Previous research has shown promising results in identifying genetic factors related to osteoarthritis, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Birmingham VA Medical Center
Birmingham, United States Active
Researchers
- Principal investigator: Mcdonald Donnelly, Merry-Lynn Noelle — Birmingham VA Medical Center
- Study coordinator: Mcdonald Donnelly, Merry-Lynn Noelle
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.