Understanding the genetics of nicotine addiction using a diverse rat panel
Pangenomics of nicotine abuse in the hybrid rat diversity panel
This research explores the genetic reasons why some people are more likely to become addicted to nicotine, using a special group of rats.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11127474 on NIH RePORTER |
What this research studies
We want to understand why individuals respond differently to nicotine and are more or less likely to become addicted. This project uses a unique group of genetically diverse rats, similar to human populations, to uncover the specific genetic differences that influence nicotine addiction. By studying these rats, we can control their exposure to nicotine and observe how genes and environment interact to affect addiction behaviors. The goal is to gather a complete picture of genetic and molecular information to help develop personalized treatments for nicotine addiction.
Who could benefit from this research
Good fit: This foundational research does not involve human participants, but future clinical applications may benefit individuals struggling with nicotine addiction, particularly adolescents and adults.
Not a fit: Patients not affected by nicotine addiction or related conditions would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new, more personalized treatments for nicotine addiction by identifying specific genetic factors that influence vulnerability.
How similar studies have performed: While the use of this specific 'hybrid rat diversity panel' is a powerful new resource, previous studies have shown that genetic factors play a significant role in addiction vulnerability.
Where this research is happening
Memphis, United States
- University of Tennessee Health Sci Ctr — Memphis, United States (Active)
Researchers
- Principal investigator: Sharp, Burt M — University of Tennessee Health Sci Ctr
- Study coordinator: Sharp, Burt M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.