Understanding the Genetics of Glaucoma
NEIGHBORHOOD Consortium for POAG Genetics
This project looks for genetic differences that cause primary open-angle glaucoma, a condition that can lead to blindness.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Eye and Ear Infirmary NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11018575 on NIH RePORTER |
What this research studies
Primary open-angle glaucoma (POAG) is a serious eye condition that can cause vision loss and blindness, and we don't fully understand why it happens or how to prevent it. While high eye pressure is a known risk factor, many people with POAG have normal eye pressure, highlighting the need for deeper understanding. This project aims to uncover the specific genetic changes, both common and rare, that contribute to POAG. By finding these genetic clues, we hope to develop better ways to screen for, prevent, and treat this condition.
Who could benefit from this research
Good fit: Patients with primary open-angle glaucoma or those with a family history of the condition might be ideal candidates for future related studies.
Not a fit: Patients without primary open-angle glaucoma or a family history of the condition may not directly benefit from this specific genetic research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to screen for glaucoma early, prevent vision loss, and develop new treatments.
How similar studies have performed: Previous large-scale genetic studies have identified several genetic regions linked to glaucoma, providing a foundation for this deeper investigation into rare genetic variants.
Where this research is happening
Boston, United States
- Massachusetts Eye and Ear Infirmary — Boston, United States (Active)
Researchers
- Principal investigator: Wiggs, Janey L — Massachusetts Eye and Ear Infirmary
- Study coordinator: Wiggs, Janey L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.