Understanding the genetics of cocaine preference using fruit flies
Official title: Systems Genetics of Cocaine Preference in Drosophila
Funded at Clemson University · NIH-10891421 · Data updated 2026-11-12
This study is looking at how our genes might affect our preference for cocaine, using fruit flies to help us understand the biological reasons behind addiction, which could lead to better treatments for people struggling with this issue.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Clemson University NIH-funded |
| Lab location | 1 site (Clemson, United States) |
| Project start | September 8, 2023 |
| Project end | September 7, 2025 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31DA057062-02 |
| Project ID | NIH-10891421 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with a family history of cocaine use disorder or those who have experienced challenges related to cocaine use.
✕Less likely to help
Patients who do not have a genetic predisposition to cocaine use disorder or who have not engaged in cocaine use may not benefit from this research.
What this research studies
This research investigates the genetic factors that influence cocaine preference by using the fruit fly Drosophila melanogaster as a model organism. By leveraging the Drosophila melanogaster Genetic Reference Panel, the study aims to identify specific genes associated with cocaine-related behaviors while controlling for environmental influences. The approach includes genome-wide association studies to uncover genetic variations that may predispose individuals to cocaine use disorder. This research could provide insights into the biological mechanisms underlying addiction and inform future treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the genetic basis of cocaine use disorder, potentially guiding the development of targeted therapies.
How similar studies have gone: Previous research using model organisms like Drosophila has shown promise in uncovering genetic factors related to various behavioral traits, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Clemson University
Clemson, United States Active
Researchers
- Principal investigator: Hatfield, Jeffrey S — Clemson University
- Study coordinator: Hatfield, Jeffrey S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.