Understanding the Genetics of Cells with Many Nuclei
Spatial genetics investigation of multinucleated cells
This project aims to understand how cells with multiple nuclei, which are important in conditions like heart disease and cancer, work at a genetic level.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project ID | NIH-11163557 on NIH RePORTER |
What this research studies
Many important body systems, including muscles and the heart, rely on special cells that have more than one nucleus. When these multinucleated cells don't work correctly, they can contribute to serious human diseases like certain cancers. Researchers want to learn how the genes within these cells are organized and how they communicate with their surroundings. By using advanced genetic tools, this project hopes to uncover the fundamental ways these unique cells function. This deeper understanding could pave the way for new ways to address diseases linked to these cells.
Who could benefit from this research
Good fit: Patients with conditions related to multinucleated cells, such as heart disease or certain cancers, could potentially benefit from future treatments developed from this basic understanding.
Not a fit: Patients seeking immediate treatment options may not directly benefit from this foundational research, as it focuses on basic biological understanding rather than direct clinical application.
Why it matters
Potential benefit: If successful, this foundational knowledge could lead to new ways to understand and potentially treat diseases involving multinucleated cells, such as heart conditions and certain cancers.
How similar studies have performed: This project explores a relatively overlooked area of biology concerning multinucleated cells, suggesting a novel approach to understanding their genetic function.
Where this research is happening
Athens, United States
- University of Georgia — Athens, United States (Active)
Researchers
- Principal investigator: Bi, Pengpeng — University of Georgia
- Study coordinator: Bi, Pengpeng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.