Understanding the genetics of cancer linked to long telomeres
Cancer Genetics of Long Telomere Syndromes
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-11142132
This study is looking at how certain genes might make people more likely to develop cancer, especially acute myeloid leukemia, if they have longer telomeres, which are the protective ends of chromosomes. If you're interested in understanding your own cancer risk, you might be invited to take part in genetic testing and monitoring.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11142132 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic factors contributing to a cancer-prone syndrome associated with long telomere lengths. It aims to explore how extended cellular longevity, which differs from traditional cancer syndromes, influences cancer risk. By analyzing genetic variations and their relationship with telomere length, the study seeks to uncover mechanisms that may lead to increased susceptibility to various malignancies, particularly acute myeloid leukemia. Patients may be involved in genetic testing and monitoring to better understand their cancer risk.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals with a family history of cancer or those diagnosed with acute myeloid leukemia and related conditions.
Not a fit: Patients with no genetic predisposition to long telomere syndromes or those without a history of related malignancies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and targeted prevention strategies for patients with long telomere syndromes.
How similar studies have performed: Previous research has shown promising results in understanding the role of telomere length in cancer risk, suggesting that this approach could yield valuable insights.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ARMANIOS, MARY Y — JOHNS HOPKINS UNIVERSITY
- Study coordinator: ARMANIOS, MARY Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.