Understanding the genetics of cancer linked to long telomeres
Official title: Cancer Genetics of Long Telomere Syndromes
Funded at Johns Hopkins University · NIH-11142132 · Data updated 2026-11-12
This study is looking at how certain genes might make people more likely to develop cancer, especially acute myeloid leukemia, if they have longer telomeres, which are the protective ends of chromosomes. If you're interested in understanding your own cancer risk, you might be invited to take part in genetic testing and monitoring.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | March 10, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $635,033 |
| NIH project number | 1R01CA292812-01A1 |
| Project ID | NIH-11142132 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include individuals with a family history of cancer or those diagnosed with acute myeloid leukemia and related conditions.
✕Less likely to help
Patients with no genetic predisposition to long telomere syndromes or those without a history of related malignancies may not benefit from this research.
What this research studies
This research investigates the genetic factors contributing to a cancer-prone syndrome associated with long telomere lengths. It aims to explore how extended cellular longevity, which differs from traditional cancer syndromes, influences cancer risk. By analyzing genetic variations and their relationship with telomere length, the study seeks to uncover mechanisms that may lead to increased susceptibility to various malignancies, particularly acute myeloid leukemia. Patients may be involved in genetic testing and monitoring to better understand their cancer risk.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and targeted prevention strategies for patients with long telomere syndromes.
How similar studies have gone: Previous research has shown promising results in understanding the role of telomere length in cancer risk, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Armanios, Mary Y — Johns Hopkins University
- Study coordinator: Armanios, Mary Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.