Understanding the Genetics of Biliary System Development
Forward genetic analysis of biliary system formation
This research aims to uncover the genetic reasons behind problems with the bile ducts, like biliary atresia, which affects infants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11094051 on NIH RePORTER |
What this research studies
Our bodies' bile ducts are crucial for liver health, but sometimes they don't form correctly, leading to serious liver conditions. This project starts by studying zebrafish to find new genes and pathways that guide how the biliary system develops. We use advanced computer tools to precisely measure differences in their bile duct patterns. Ultimately, we will apply what we learn from these models to human patient samples to better understand diseases like biliary atresia.
Who could benefit from this research
Good fit: Patients with biliary atresia or other cholestatic liver diseases, particularly infants, are the focus of this research, though direct participation is not currently part of the grant.
Not a fit: Patients without biliary system conditions would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of the causes of biliary system diseases, potentially paving the way for new ways to prevent or treat them.
How similar studies have performed: This project builds on successful prior work identifying new genetic mutations in zebrafish that affect the biliary system, extending a novel approach to human disease.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Sakaguchi, Takuya — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Sakaguchi, Takuya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.