Understanding the Genetics of Balance Problems in Older Adults
The genetics of functional decline in the aging vestibular system: A GWAS and gene expression analysis in aging mice and humans
This project aims to discover the genetic factors that contribute to balance issues and falls in older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11097294 on NIH RePORTER |
What this research studies
Falls are a serious concern for older adults, often linked to problems with the inner ear's balance system. This project looks at the genetic makeup of both humans and mice to find common genes and pathways involved in age-related balance decline. By comparing large genetic datasets and analyzing gene activity in balance-related tissues, researchers hope to pinpoint specific areas that can be targeted for future treatments. The goal is to better understand why balance worsens with age, paving the way for new ways to prevent falls.
Who could benefit from this research
Good fit: Ideal candidates are older adults experiencing dizziness or falls, or those interested in the genetic causes of age-related balance issues.
Not a fit: Patients whose balance issues are not related to age or the vestibular system may not directly benefit from this specific genetic research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments or preventive strategies for age-related balance problems and falls.
How similar studies have performed: Previous smaller genetic studies have identified some genes linked to falls in older adults, providing a foundation for this larger analysis.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Friedman, Rick a — University of California, San Diego
- Study coordinator: Friedman, Rick a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.