Understanding the genetics of Alzheimer's disease using human stem cells
Towards a better understanding of genetic architecture of Alzheimer's disease with human iPSC models
This study is looking at how certain genes might play a role in Alzheimer's disease by using special cells to see how these genes affect brain function, with the hope of finding better ways to treat the disease for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10833062 on NIH RePORTER |
What this research studies
This research investigates the genetic factors contributing to Alzheimer's disease by utilizing human induced pluripotent stem cells (hiPSCs). The approach involves gene editing and advanced multi-omics analyses to explore how specific genetic variants influence cellular functions related to Alzheimer's. By focusing on the cellular and molecular pathways affected by these genetic variants, the research aims to provide insights into the disease's progression and potential therapeutic targets. Patients may benefit from a deeper understanding of the genetic underpinnings of Alzheimer's, which could lead to more personalized treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those diagnosed with early-onset Alzheimer's.
Not a fit: Patients with non-genetic forms of dementia or those without a familial link to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in using similar approaches to dissect genetic contributions to complex diseases, indicating potential for success in this area.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Wen, Zhexing — Emory University
- Study coordinator: Wen, Zhexing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.