Understanding the Genetics of Alzheimer's Disease Types
Genetic Architecture of Pure Alzheimer's Disease and Mixed Pathology
This project aims to understand the genetic differences between pure Alzheimer's disease and Alzheimer's disease that occurs with other brain changes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11086114 on NIH RePORTER |
What this research studies
Many people with Alzheimer's disease also have other brain conditions like Lewy bodies or small strokes, which can make their symptoms different. We want to find out if the genetic causes are different for people who have only Alzheimer's changes in their brain compared to those who have Alzheimer's along with other conditions. By looking closely at brain tissue and genetic information, we hope to uncover specific genetic patterns linked to each type of Alzheimer's. This will help us better understand why Alzheimer's affects people differently.
Who could benefit from this research
Good fit: This research primarily uses existing brain tissue and genetic data from individuals who have passed away and had their brains donated for scientific study, particularly those with confirmed Alzheimer's disease or other brain pathologies.
Not a fit: Patients currently living with Alzheimer's disease will not directly participate in or receive immediate treatment from this specific genetic analysis.
Why it matters
Potential benefit: If successful, this work could lead to more accurate diagnoses and the development of new treatments tailored to specific genetic profiles of Alzheimer's disease.
How similar studies have performed: While previous genetic studies have looked at Alzheimer's, this approach is novel in its detailed distinction between pure and mixed Alzheimer's pathologies using advanced statistical and multi-omics methods.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Mukherjee, Shubhabrata — University of Washington
- Study coordinator: Mukherjee, Shubhabrata
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.