Understanding the genetics of Alzheimer's disease and related dementias
Genomics Core
This study is looking at how our genes and their activity might affect the development and progression of Alzheimer's disease and related dementias, helping us learn more about the condition from its early stages to more advanced ones.
Quick facts
| Grant type | P30 center grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10870032 on NIH RePORTER |
What this research studies
This research focuses on the genetic and epigenetic factors that contribute to Alzheimer's disease (AD) and related dementias (ADRD). By studying individuals from the earliest stages of the disease through to advanced stages, the research aims to uncover how genetic variations and changes in gene expression influence disease progression. The Genomics Core will extract DNA from biosamples, perform genetic testing, and analyze epigenetic markers to better understand the complexities of AD. This collaborative effort will enhance the resources available for genomics research within the Alzheimer's Disease Research Center.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals diagnosed with Alzheimer's disease or related dementias, particularly those from diverse backgrounds, including African American populations.
Not a fit: Patients with non-genetic forms of dementia or those not diagnosed with Alzheimer's disease or related dementias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potentially new treatments for Alzheimer's disease and related dementias.
How similar studies have performed: Previous research has shown success in understanding genetic factors in Alzheimer's disease, making this approach both relevant and promising.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Van Deerlin, Vivianna M — University of Pennsylvania
- Study coordinator: Van Deerlin, Vivianna M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.